Getting rid of Tumor Suppressive Cells might help get rid of the Long List of Old-Age associated Ailments & How a 17-year-old’s Robust Compilation provides Solutions to it?

“Imagine getting old without actually being old, imagine extending the number of years that we live, imagine being as fit & healthy as a teenager even in our 70’s”, Well Lakshya Sharma, a Grade 12 student of Delhi Public School, Sector 45, Gurgaon is the youngest researcher in India who is initiating and articulating this novel research field in India. 

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“One of the ideas around what are known as senescent or tumor suppressive cells is that they arise as a mechanism to protect the body from the formation of tumors and in turn protect us from cancer. The cells stop dividing themselves and hence prevent the formation of a tumor. Once these cells have completed their job for prevention of cancer they are no longer necessary and accumulate in the body as we age. So a person who is 70 years old is having more number of senescent cells than a person who is 20 years old. As they accumulate these cells have negative effects on the body, ironically leading to Cancer and age-related chronic diseases like Hearing Loss, Vision Loss, Osteoarthritis (Loss of Cartilage), Osteoporosis (Weakening of Bones), Memory Loss, Diabetes, Sarcopenia, Subcutaneous Fat Loss, etc. Getting rid of these cells has resulted in increase in the average lifespan and healthspan (what I mean by healthspan is the number of years a person lives without age-related chronic diseases like Hearing Loss, Vision Loss, Osteoarthritis, Osteoporosis, Memory Loss, Diabetes, Sarcopenia, Subcutaneous Fat Loss, etc.) in mice models.”, said Lakshya Sharma who is the youngest publisher in the field of Senescence with his publication “Cellular Senescence & Secretory Phenotypes through the lens of Ageing, In Vivo Reprogramming Technology”. 

Figure 1: The process of the transformation of a normal (stem) cell to a senescent cell due to the stress, damage in the tissue environment. The senescent cells tend not to die throughout the lifespan and release certain molecules (Senescence Associated Secretory Phenotype) that trigger inflammation in the tissue environment leading to Cancer, Osteoarthritis (Loss of Cartilage), Osteoporosis (Weakening of Bones) & other age-related diseases. 

Source: National Institute on Aging. “Does Cellular Senescence Hold Secrets for Healthier Aging?” Accessed December 24, 2021. http://www.nia.nih.gov/news/does-cellular-senescence-hold-secrets-healthier-aging.

“Researchers at American Institutes like the Buck Institute of Aging and Mayo Clinic have studied mice models (since the DNA/Biochemistry of a mouse is similar to a human) where they have studied two different mice - 1 having senescent cells and 1 not having senescent cells. The mouse with senescent cells was shown to be suffering from age-related chronic diseases like Sarcopenia, Subcutaneous Fat Loss, Osteoarthritis, Osteoporosis, Vision Loss, etc. and the mouse without senescent cells lived 25-35% longer without any age-related diseases as compared to the mouse having senescent cells. If these senescent cells are major drivers of age-related diseases in humans, we can use their removal as therapeutic mechanisms for age-related diseases for increase in Lifespan & Healthspan”, said Lakshya Sharma who is the only teenager in India stimulating and generating a possible solution to Tumor Suppressive Networks in the near future with the help of Professors at IIT’s and Research & Development Heads of Various Multinational Companies and is a published author in International Journals like the Expert Review of Proteomics.

Figure 2: Genetically altered similar mice as utilised by the experiments carried out at the Buck Institute of Aging & Mayo Clinic, USA. Left: Mice with Senescent cells; Right: Mice without Senescent Cells.

Source: Unity Biotechnology • Developing therapeutics to slow, halt, or reverse diseases of aging. “The Science • Unity Biotechnology,” April 11, 2018. https://unitybiotechnology.com/the-science/.

“Currently there are very few people working on senescence throughout the world since this is a relatively newer research field. We need to be working on certain Senolytic Drugs that would help in the removal of senescent cells from the body. Successful senolytic drugs have been tested on mice and currently, there are Phase 1 clinical trials being run in the USA where they are testing Senolytic Drugs on Humans. I have recently been invited as an academic researcher (Research Intern) at IIT Delhi in the summer for a couple of months for drug development where I hope to find a possible solution to the removal of senescent cells with the formation of Senolytic Drugs for Humans. If successful, this discovery might revolutionize modern medicine as there would be no requirement of a doctor specialising in Heart, Lungs, Eye, etc. The only thing essential to increase our healthspan and possibly lifespan would be the removal of senescent cells leading to treatment of the age-related diseases. I have worked as an academic researcher (Research Intern) for a couple of months individually in the past of couple of years at various Indian Research Institutions like IIT Bombay, IIT Kanpur, IIT Jammu, IIT BHU, IIT Ropar, IISC Bangalore under professors along with companies like Solvay where I was chosen as a researcher based on my academic competency, previous experiences, research papers & my book. My experience at IIT Bombay Proteomics Laboratory helped me understand the topic of Protein Analysis in Cancer which motivated me to write my own book. I have been recently recognised by the Director of the Defence Research Development Organisation (DRDO), India (the premier research institution of the government of India) for my research efforts”, said Lakshya who is pioneering the project to engineer Biopharmaceutical Drugs for suppressing the Senescent Cells. 

“Lakshya has an excellent scientific aptitude and is proficient in understanding scientific literature at a very young age,'' said Respected Professor Dr. Gaurav Ashok Bhaduri, an Assistant Professor at IIT Jammu who has completed his Post-Doctoral Studies from IIT Kharagpur. “Lakshya's ability to research is exemplary and the kind of experiences he has already built at such a tender age are commendable”, said Respected Professor Dr. Sarang P. Gumfekar, an Assistant Professor at IIT Ropar who has completed his PhD. studies from University of Alberta, Canada. “Lakshya’s quest for finding a possible solution to aging along with senolytic drug development would surely be a success seeing his current research aptitude and research experiences along with his publication. Reviewing Lakshya’s research works makes me believe that his book would be a great introduction and asset for future research groups in India”, said Respected Professor Dr. Manoj Kashyap, an Associate Professor at the Stem Cell Institute who has completed his PhD. studies from Johns Hopkins University, USA in Cancer Biology.

Figure 3: Lakshya Sharma, a student at Delhi Public School, Sector 45, Gurgaon and his published book “Cellular Senescence & Secretory Phenotypes through the lens of Ageing, In Vivo Reprogramming Technology”. 

Supplementary Links: 

  1. https://fas.org/blogs/sciencepolicy/extending-human-life-with-senescent-cell-treatments/
  2. https://www.nytimes.com/2011/11/03/science/senescent-cells-hasten-aging-but-can-be-purged-mouse-study-suggests.html
  3. https://www.theguardian.com/science/2018/oct/06/race-to-kill-killer-zombie-cells-senescent-damaged-ageing-eliminate-research-mice-aubrey-de-grey
  4. https://www.nia.nih.gov/news/does-cellular-senescence-hold-secrets-healthier-aging
  5. https://www.youtube.com/watch?v=uZiv_0nzv24
  6. https://www.euronews.com/next/2021/12/14/can-we-live-forever-new-anti-ageing-vaccine-could-bring-immortality-one-step-closer
  7. https://economictimes.indiatimes.com/news/science/new-class-of-drugs-may-dramatically-increase-healthy-lifespan/articleshow/46529610.cms?from=mdr
  8. https://www.mayoclinic.org/medical-professionals/endocrinology/news/senescent-cells-promising-anti-aging-targets-for-health-span-extension-and-the-treatment-of-osteoporosis/mac-20431073
  9. https://pubmed.ncbi.nlm.nih.gov/29988130/
  10. https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(19)30641-3/fulltext
  11. https://embryo.asu.edu/pages/hayflick-limit
  12. https://www.livescience.com/16845-longevity-aging-cellular-cleaning.html
  13. https://www.theatlantic.com/science/archive/2016/02/clearing-retired-cells-extends-life/459723/
  14. https://www.technologyreview.com/2016/02/03/162446/in-new-anti-aging-strategy-clearing-out-old-cells-increases-life-span-of-mice-by-25-percent/
  15. https://www.tampabay.com/archive/2011/11/03/purge-cells-stay-young/
  16. https://www.statnews.com/2018/07/09/aging-senolytics-senescent-cells/
  17. https://www.discovermagazine.com/planet-earth/extending-healthy-life-by-getting-rid-of-retired-cells
  18. https://www.healthline.com/health-news/anti-aging-treatment-that-kills-zombie-cells
  19. https://www.genengnews.com/insights/senolytics-to-tackle-age-related-pathologies/
  20. https://www.scientificamerican.com/article/to-stay-young-kill-zombie-cells/
  21. https://medium.com/@kheni/senescent-cells-b7b63215671f
  22. https://www.youtube.com/watch?v=w-jLAs4qHsY

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